Low Dose Naltrexone (LDN) is a custom-compounded form of the medication naltrexone, originally approved in 50 mg doses to treat opioid or alcohol dependence. When prescribed at much lower doses (typically 0.5 mg to 4.5 mg), it works differently, helping the body balance immune function, reduce inflammation, and naturally boost endorphins.
Because LDN is not commercially manufactured in these lower strengths, it must be prepared by a compounding pharmacy under a prescriber’s direction. At Central Iowa Compounding Pharmacy, we work closely with your healthcare provider to create a formulation and dose that’s tailored to your needs.
Central Iowa Compounding is proudly a member of LDN Research Trust.
LDN gently and temporarily blocks opioid receptors for a short time. This brief interruption signals the body to produce more of its own endorphins, the hormones responsible for well-being, pain control, and immune regulation.
By restoring this natural balance, LDN may help:
While ongoing research continues, healthcare professionals have used Low Dose Naltrexone as part of therapy for a variety of immune-related and inflammatory conditions, including:
Autoimmune disorders such as Hashimoto’s thyroiditis, lupus, rheumatoid arthritis, and multiple sclerosis
Chronic pain syndromes like fibromyalgia and neuropathy
Inflammatory bowel conditions such as Crohn’s disease and ulcerative colitis
Skin and neurological disorders linked to inflammation
Integrative care approaches for cancer-related fatigue or immune imbalance
LDN is not a cure but may be used as an adjunct therapy to support symptom management and wellness under your provider’s supervision.
At Central Iowa Compounding Pharmacy, we prepare customized LDN formulations in a variety of strengths and dosage forms to meet each patient’s needs, including:
Capsules in gradual titration strengths (e.g., 1.5 mg → 3 mg → 4.5 mg)
Topical creams or oral suspensions for those who prefer non-capsule options
Dye-free, lactose-free, or preservative-free preparations for sensitive patients
This personalized approach ensures precision dosing and improved tolerability, mass-produced medications simply can’t provide.
Standard naltrexone (50 mg) is used to block opioid effects for addiction treatment. At much lower doses, LDN works by stimulating the body’s natural endorphin production and modulating the immune system.
When prescribed and monitored by your healthcare provider, LDN is generally well tolerated. Some patients may experience vivid dreams or mild sleep changes during the first week, which often resolve quickly.
Every patient is different. Some may notice improvements in mood, sleep, or energy within a few weeks; others may take several months of consistent use.
Commercial manufacturers only produce naltrexone in 50 mg tablets, too strong for LDN dosing. Our compounding team prepares the precise low-dose formulation your prescriber orders.
LDN should not be used with opioid-containing medications. Always review your full medication list with your prescriber and pharmacist before starting LDN.
Most patients take LDN once daily at bedtime, though your prescriber may adjust timing and dose based on your condition and response.
Yes. A licensed healthcare provider must prescribe Low Dose Naltrexone. Central Iowa Compounding Pharmacy will then prepare your custom medication exactly as ordered.
At Central Iowa Compounding Pharmacy, our mission is to make advanced, personalized therapies like Low Dose Naltrexone accessible to patients across Iowa. We collaborate closely with providers, ensuring quality ingredients, precise compounding methods, and exceptional patient care every step of the way.
Have questions about LDN or want to learn more about compounded medications?
Visit or call Central Iowa Compounding Pharmacy to speak with our compounding specialists today.
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